Change in director’s responsibilities, change to the board and renewal of cautionary announcement Ascendis Health Limited (Registration number 2008/005856/06) (Incorporated in the Republic of South Africa) Share code: ASC ISIN: ZAE000185005 (“Ascendis Health” or “the Company”) Change in director’s responsibilities, change to the board and renewal of cautionary announcement 1. Acting Chief Executive Officer Shareholders are referred to the announcement released on SENS on 23 May 2019, in which the Company advised, inter alia, that Mr Andrew Marshall, the current chairman of the board of directors of the Company (“Board”), will be acting as chief executive officer (“CEO”) until the Board has appointed a suitable candidate to fill this role. The Board anticipates that it will make the appointment of a new CEO within three months. 2. Lead Independent Non-Executive Director In accordance with paragraph 3.59(c) of the JSE Limited Listings Requirements, the Board is pleased to advise shareholders that Mrs Bharti Harie, currently an independent non-executive director and chair of the Company’s audit and risk committee, has been appointed to fulfil the role of lead independent non-executive director of the Company with effect from 7 June 2019. 3. Change to the Board Shareholders are further advised that Mr Phil Roux has resigned as a non-executive director of Ascendis Health with effect from 7 June 2019. The Board is of the collective view that Phil could offer greater value to the Company in a consulting role. The Board has requested that he consult on an ongoing basis and he has agreed to this role, and we look forward to utilising his extensive experience within the group’s local and international operations. The Board will commence a search for an additional independent non-executive director. 4. Renewal of Cautionary Announcement Shareholders are further referred to the cautionary and cautionary renewal announcements published on SENS on 14 January 2019, 8 February 2019, 8 March 2019 and 24 April 2019, respectively, relating to an unsolicited offer received for the Remedica business unit (“Remedica”) in Cyprus. Ascendis Health is involved in ongoing negotiations regarding the potential disposal of Remedica and will update investors should a transaction be concluded. Shareholders are advised to continue to exercise caution when dealing in the Company’s securities until a further announcement is made. 7 June 2019 Johannesburg Sponsor Questco Corporate Advisory Proprietary Limited Date: 07/06/2019 12:30:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.